Clinical assessment of DSM-IV anxiety disorders in fragile X syndrome: prevalence and characterization

Table 4 Comparison of anxiety disorder prevalence rates among FXS with ID vs. Idiopathic ID, FXS without ID vs. General Population and FXS vs. Williams Syndrome

	ID comparison^a		Non-ID comparison^b		Genetic syndrome comparison^c
Anxiety type	FXS + ID	ID^d	FXS-ID	Gen. Pop.^e	FXS	WS^f
Any anxiety disorder	87.9%^*	10.5%	76.3%^*	9.8%	82.5%^*	62.1%
Separation anxiety	10.3%	1.9%	13.5%^*	2.3%	11.5%	6.1%
Social phobia	32.8%^*	1.9%	43.2%^*	4.5%	36.5%^*	2.3%
Specific phobia	70.7%^*	6.8%	42.9%^*	1.3%	59.6%	56.1%
Panic Disorder	6.9%	N/A	2.9%	N/A	5.4%	N/A
-Agoraphobia	1.7%	0.2%	0.0%	N/A	1.1%	N/A
+Agoraphobia	5.2%^*	0.2%	0.0%	N/A	3.2%	N/A
Agoraphobia	17.9%^*	1.1%	5.6%	1.4%	12.9%	N/A
GAD	21.4%^*	0.0%	27.8%^*	3.1%	23.7%^*	7.6%
OCD	26.8%^*	1.5%	19.4%	N/A	23.7%^*	1.5%
PTSD	1.7%	0.0%	8.6%	N/A	4.3%	1.5%
Selective mutism	27.6%	N/A	22.2%	N/A	25.3%	N/A

^aControl for multiple comparisons used, significant differences are p<.0025
^bControl for multiple comparisons used, significant differences are p<.00417
^cControl for multiple comparisons used, significant differences are p<.00357
^dDekker (2003) using DISC-IV-P, N = 474, ^eSchaffer (1999) using DISC 2.3, N = 1,285, ^fLeyfer (2009) N = 132 using ADIS-IV
^* Difference is significant at the corrected (p) value

ISSN: 1866-1955