Fig. 1

Functional connectivity differences between term and very preterm infants. a Left: group mean amygdala resting state-functional connectivity correlation maps for full-term and very preterm infants scanned at term equivalent postmenstrual age; right: z scores demonstrating group differences in connectivity obtained from voxelwise t test. Blue voxels denote areas with greater negative correlations and orange voxels denote areas with greater positive correlations in term infants. Results thresholded using |z| > 2.25 and 53 contiguous voxels achieving whole-brain false-positive rate of 0.05. Adapted with permission from Rogers CE, et al. JAACAP. 2017; 56(2):157-166. b Left: group mean covariance matrices representing multiple canonical RSNs for full-term and very preterm infants at term equivalent postmenstrual age; right: difference between these two results (term minus preterm). Black stars denote cells with between group difference on two-tailed Mann-Whitney U test (p < 0.05; multiple comparisons uncorrected). Adapted with permission from Smyser CD, et al. Cerebral Cortex. 2016; 26(1):322-333. c Functional connections important for differentiating full-term versus very preterm infants using support vector machine-multivariate pattern analysis to analyze data from 244 regions of interest located throughout the brain. Connections stronger in term infants are shown in green; those stronger in very preterm infants are in orange. The caliber of each connection is weighted by the difference magnitude. Adapted with permission from Smyser CD, et al. NeuroImage. 2016; 136:1-9