Quantitative trait variation in ASD probands and toddler sibling outcomes at 24 months

Table 4 Linear regression analyses: VABS-II parent-reported behavior

	Beta^a	95% CI lower	95% CI upper	p value
ABC model (n = 303)
Proband ABC	0.33	0.11	0.55	0.004⁺
Sibling sex	− 0.27	− 0.48	− 0.07	0.009
Group	0.99	0.75	1.23	< 0.0001
Proband score x group	− 0.18	− 0.43	0.07	0.149
SOC model (n = 311)
Proband SOC	0.25	0.04	0.46	0.022
Sibling sex	− 0.33	− 0.53	− 0.14	0.001
Group	0.88	0.64	1.12	< 0.0001
Proband score x group	− 0.21	− 0.45	0.03	0.089
COM model (n = 309)
Proband COM	0.40	0.20	0.61	< 0.0001⁺
Sibling sex	− 0.16	− 0.35	0.04	0.113
Group	1.07	0.83	1.30	< 0.0001
Proband score x group	− 0.28	− 0.51	− 0.04	0.021
EL model (n = 317)
Proband EL	0.44	0.23	0.65	< 0.0001⁺
Sibling sex	− 0.23	− 0.44	− 0.03	0.028
Group	0.80	0.55	1.04	< 0.0001
Proband score x group	− 0.36	− 0.60	− 0.12	0.003⁺
RL model (n = 318)
Proband RL	0.53	0.32	0.73	< 0.0001⁺
Sibling sex	− 0.08	− 0.27	0.12	0.429
Group	1.05	0.82	1.28	< 0.0001
Proband score x group	− 0.42	− 0.65	− 0.19	< 0.0001⁺
GM model (n = 277)
Proband GM	0.22	− 0.05	0.50	0.113
Sibling sex	0.03	− 0.22	0.27	0.832
Group	0.55	0.27	0.84	< 0.0001
Proband score x group	− 0.01	− 0.32	0.29	0.933

ABC Adaptive Behavior Composite, SOC socialization composite, COM communication composite, EL expressive language, RL receptive language, GM gross motor
^aStandardized beta coefficients from linear regression models. Reference groups for sibling sex and group are female (vs. male) and ASD (vs. no ASD), respectively. Full model results are shown in Additional file 1: Table S4
⁺significant at p ≤ 0.004 after Bonferroni correction for main and interacting effects of proband score (12 comparisons)

ISSN: 1866-1955