Fig. 1

MSEL nonverbal developmental quotient score trajectory by group and timepoint. Model-generated differential trajectories of derived Nonverbal Developmental Quotient (NVDQ) from the MSEL by group and timepoint (Visit). The FXS group exhibited significantly delayed trajectories of NVDQ from all other groups from 6–24 months. By 12 months of age a pattern emerged between all groups (Table 3) that persisted through 24 months, such that control > FH-nonASD > FH-ASD > FXS