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Table 5 Factors associated with sleep difficulties in children with ASD.

From: Sleep disturbances are associated with greater healthcare utilization in children with autism spectrum disorder

 

Crude OR

(99% CI)

Adjusted ORa

(99%CI)

Adjusted ORb

(99%CI)

Adjusted ORc

(99%CI)

Co-occurring Chronic Conditions

1.18

(0.75, 1.83)

1.04

(0.64, 1.69)

  

 Symptoms, Signs, And Ill-Defined Conditions

1.67

(0.92, 3.03)

1.70

(0.90, 3.22)

  

 Multiple condiitons (3 or more)

1.62

(0.88, 3.00)

1.58

(0.81, 3.08)

  

Medication Use

1.72

(1.09, 2.71)

1.47

(0.89, 2.43)

1.36

(0.90, 2.62)

 

 Medications for sleep difficulties (Melatonin and Promethazine)

2.03

(0.99, 4.16)

1.72

(0.80, 3.70)

1.72

(0.80, 3.70)

 

 Medications, excluding those for sleep difficulties

1.50

(0.93, 2.41)

1.28

(0.76, 2.15)

1.31

(0.74, 2.31)

 

 Mental and Mood Conditions

2.08

(0.85, 5.06)

1.62

(0.59, 4.47)

1.62

(0.58, 4.51)

 

Emergency Room Visits (Yes/No)

1.56

(0.96, 2.54)

1.75

(1.03, 2.98)

1.76

(1.03, 3.00)

1.72

(1.01, 2.95)

Primary Care Visits (Yes/No)

1.00

(0.98, 1.02)

1.00

(0.98, 1.02)

1.00

(0.98, 1.02)

1.00

(0.99, 1.02)

Specialist Visits (Yes/No)

1.08

(0.69, 1.70)

1.21

(0.74, 1.98)

1.21

(0.74, 1.98)

1.17

(0.71, 1.91)

Hospitalizations (Yes/No)

2.33

(1.06, 5.10)

2.82

(1.15, 6.89)

2.83

(1.15, 6.94)

2.71

(1.10, 6.67)

  1. Abbreviations: Autism Spectrum Disorder (ASD), Children’s Sleep Habits Questionnaire (CSHQ), Odds Ratio (OR)
  2. ORs were calculated using the logistic regression formula: Ln (Odds(Yi)) = a + biXi, where i = 1 for sleep disturbances and i = 0 for no sleep disturbances
  3. a Adjusted for sociodemographic variables (sex, ethnicity, age, and DSM-V category B)
  4. b Additionally adjusted for chronic comorbidities
  5. c Additionally adjusted for medication use