Fig. 3

Temporal pattern of the different sleep stages in Dup15q mutant mice and controls. Temporal pattern of NREM sleep in 24-h baseline continuous sleep recording in matDp/ + (A), patDp/ + (B), and Ube3a OE (C) mice compared to their littermate controls. Total NREM sleep time in matDp/ + (D), patDp/ + (E), and Ube3a OE (F) mice. Temporal pattern of REM sleep in matDp/ + (G), patDp/ + (H), and Ube3a OE (I) mice compared to their littermate controls. Total REM sleep time in matDp/ + (J), patDp/ + (K), and Ube3a OE (L). Number of brief arousals (M–O) and time to sleep onset (P-R) compared between mutants and WT controls in the matDp/ + , patDp/ + , and Ube3a OE groups. In panels A-C and G-I, the background shading represents the dark period