Journal of Neurodevelopmental Disorders

Table 2 Altered nodal profiles in GHD and typically developing controls

From: Altered individual-level morphological similarity network in children with growth hormone deficiency

Brain regions	Category	P-value
Brain regions	Category	\({D}_{i}^{auc}\)	\({E}_{i}^{auc}\)	\({B}_{i}^{auc}\)
GHD > TDs
IFGoperc.L	CEN	0.033^*	0.439	0.007^*
ORBinf.L	CEN	0.010^**	0.011^*	0.862
ACG.R	Limbic	0.009^*	0.044^*	0.804
PCG.R	Limbic	0.047^*	0.607	0.002^**
HIP.L	Limbic	0.088	0.455	0.022^**
PAL.L	Striatum	0.064	0.257	<0.001^**
PAL.R	Striatum	0.001^**	0.009^*	0.004^*
THA.L	Thalamus	0.005^**	0.032^*	0.823
THA.R	Thalamus	0.005^**	0.019^**	0.167
Cbe4-5.L	Cerebellum	0.014^*	0.034^*	0.365
Cbe4-5.R	Cerebellum	0.001^**	0.010^**	0.420
Cbe6.R	Cerebellum	0.005^*	0.032^*	0.614
GHD < TDs
ORBsupmed.L	DMN	0.008^*	0.015^**	0.021^*
AMYG.L	Limbic	0.006^*	0.034^**	0.015^*
AMYG.R	Limbic	0.005^**	0.001^**	0.192
LING.R	VN	0.042^*	0.034^**	0.846
PCL.L	SMN	0.016^*	0.001^**	0.433
PCL.R	SMN	0.104	0.034^**	0.251
STG.R	AN	0.120	0.034^**	0.257
Cbe3.L	Cerebellum	0.027^*	0.015^*	0.686
Cbe3.R	Cerebellum	<0.001^**	<0.001^**	0.009^*
Cbe10.L	Cerebellum	0.614	0.034^**	0.348
Cbe10.R	Cerebellum	0.404	0.021^**	0.153
Ver1-2	Cerebellum	<0.001^**	<0.001^**	0.003^**
Ver3	Cerebellum	<0.001^**	<0.001^**	<0.001^**
Ver4-5	Cerebellum	0.021^**	0.001^**	0.234
Ver6	Cerebellum	0.006^*	0.021^**	0.561

27 regions with P-value <0.05 in at least one node profile were included.
Abbreviations:\({D}_{i}^{auc}\) nodal degree, \({E}_{i}^{auc}\) nodal efficiency, \({B}_{i}^{auc}\) nodal betweenness, GHD growth hormone deficiency, TDs typically developing controls, L left, R right, IFGoperc Inferior frontal gyrus, opercular part, ORBinf Inferior frontal gyrus, orbital part, ACG Anterior cingulate and paracingulate gyri, PCG Posterior cingulate gyrus, HIP Hippocampus, PAL Lenticular nucleus, pallidum, THA Thalamus, Cbe4-5 Cerebellum 4-5, Cbe6 Cerebellum 6, ORBsupmed Superior frontal gyrus, medial orbital, AMYG Amygdala, LING Lingual gyrus, PCL Paracentral lobule, STG Superior temporal gyrus, Cbe3 Cerebellum 3, Cbe10 Cerebellum 10, Ver1-2 Vermis 1-2, Ver3 Vermis 3, Ver4-5 Vermis 4-5, Ver6 Vermis 6, CEN central executive network, SMN sensorimotor network, DMN default-mode network, SN salience network, VN visual network, AN auditory network
^*Uncorrected P < 0.05; ^**P_FDR < 0.05

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ISSN: 1866-1955

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