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Table 4 Prenatal history, birth, early postnatal behavior and feeding. [A] nominal variables (N and %), and [B] quantitative variables (mean ± SD, range). Sample size: N = 70 unless otherwise specified

From: Clinical, developmental and serotonemia phenotyping of a sample of 70 Italian patients with Phelan-McDermid Syndrome

A. variable (sample size)

N

%

Spontaneous abortions

(N = 65)

0–1 spontaneous abortions

62

88.6%

2 or more spontaneous abortions

3

4.3%

Difficulty at conception

(N = 63)

No difficulty reported

53

75.7%

Delayed conception (> 6 months)

9

12.9%

In vitro fertilization

1

1.4%

Prenatal obstetric complications

Absent

36

51.4%

Present

34

48.6%

• Early bleedings (I trimester)

11

15.7%

• Early contractions (I trimester)

2

2.9%

• Late bleedings (III trimester)

1

1.4%

• Late contractions (III trimester)

1

1.4%

• Gestational diabetes

1

1.4%

• Immune activation due to infection or allergies

1

1.4%

• IntraUterine Growth Retardation

3

4.3%

• Isthmic cervical incontinence

1

1.4%

• Placenta previa

1

1.4%

• Preterm placental calcifications

1

1.4%

• Placental abruption

1

1.4%

• Two or more complications

10

14.3%

Pharmacological treatments during pregnancy

No drug treatment

42

60.0%

Treatment for obstetric complication

17

24.3%

Drugs for other medical conditions

9

12.9%

Both obstetric and medical treatments

2

2.9%

Pregnancy duration

Born at term (37–42 wks)

55

78.6%

Post-term (> 42 wks or induced at 41–42 wks)

8

11.4%

Late preterm (34- < 37 wks)

7

10.0%

Delivery

Eutocic

30

42.9%

Dystocic

4

5.7%

Labor induction

7

10.0%

Programmed cesarean section

20

28.6%

Emergency cesarean section

9

12.9%

Postnatal obstetric complications

No complications

35

50.0%

Minor (no need for intensive care)

19

27.1%

Major (admitted to intensive care)

16

22.9%

Breastfeeding

Baby was breastfed

40

57.1%

No breastfeeding for maternal issues

8

11.4%

No breastfeeding for baby issues

22

31.4%

Strength in sucking milk

Normal strength in sucking milk

40

57.1%

Weak sucking behavior

30

42.9%

Coordination in swallowing

(N = 69)

Coordinated swallowing

51

73.9%

Uncoordinated swallowing

18

26.1%

Gastroesophageal reflux

(N = 68)

Absent

43

61.4%

Present

25

35.7%

Weaning

Difficulty with chewing and swallowing semisolid foods

30

42.9%

B. Variable

N

Mean

Range

Birth weight (kg)

70

3.15 ± 0.55

1.5–4.4

Birth length (cm)

65

49.35 ± 2.33

41.0–54.0

Apgar score at 1 min

61

8.64 ± 1.55

2–10

Apgar score at 5 min

59

9.46 ± 1.30

3–10

Breastfeeding duration (months)

56

7.76 ± 8.77

0.4–36