Table 1 Participant characteristics
Variable | XXY/KS cohort | Test for difference | XYY cohort | Test for difference | XXY/KS vs. XYY | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | XXY/KS probands | XY controls | Test statistic | p-value | XYY probands | XY controls | Test statistic | p-value | Statistic | p-value |
Sample size | Â | 102 | 74 | - | - | 64 | 60 | - | - | - | - |
Age (years) | Mean (sd) | 16.2 (4.98) | 17.1 (5.63) | t = 1.12 | 0.27 | 13.1 (6) | 13.1 (5) | t = 0 | 1 | t = 3.6 | 0.0005 |
Range | 6–25 | 6–25 | - | - | 5–25 | 5–25 | - | - | - | - | |
Full Scale IQ | Mean (sd) | 92.8 (12.4) | 116.0 (13.1) | t = 11.6 |  < .0001 | 86 (14) | 117 (11) | t = -5.3 |  < 0.0001 | t = 3.14 | 0.0021 |
Range | 64–127 | 83–146 | - | - | 53–112 | 88—144 | - | - | - | - | |
SES | Mean (sd) | 48.2 (20.7) | 39.6 (18.6) | t = -2.9 | 0.005 | 53 (19) | 39 (16) | t = 4.4 |  < 0.0001 | t = -1.44 | 0.153 |
Range | 20—77 | ||||||||||
|  | 20–120 | 20–95 | - | - | 20–95 | - | - | - | - | - | |
Gestation (weeks) | Mean (sd) | 38.9 (1.85) | - | - | - | 38 (2) | 39.2 (2) | t = -2.9 | 0.0004 | t = 1.64 | 0.104 |
Range | 32.5–42 | - | - | - | 31–42 | 32—42 | - | - | - | - | |
Birthweight (kg) | Mean (sd) | 3.28 (0.47) | - | - | - | 3.26 (0.6) | 3.55 (0.5) | t = -2.8 | 0.006 | t = 0.56 | 0.577 |
Range | 1.8–4.5 | - | - | - | 1.6–4.5 | 2.5—4.7 | - | - | - | - | |
Time of SCA diagnosis | Prenatal, n (%) | 38 (37%) | - | - | - | 25 (39%) | - | - | - | χ2 = 0.005 | 0.94 |
Postnatal, n (%) | 64 (63%) | - | - | - | 39 (61%) | - | - | - | - | - | |
Vineland Adaptive Behavior Composite Score (VABC) | Mean (sd) | 77.4 (14.7) | - | - | - | 76 (13) | - | - | - | t = .522 | 0.602 |
Range | 41–111 | - | - | - | 42–112 | - | - | - | - | - | |
Caregiver Strain Questionnaire Global Score (CSQ) | Mean (sd) | 6 (2.39) | - | - | - | 7.1 (2.79) | - | - | - | t = -2.57 | 0.012 |
Range | 3–12.5 | - | - | - | 3–14.3 | - | - | - | - | - | |