Fig. 2

Seizure frequency, medication, and infantile spasms in individual TSC participants. Data reflect 49 participants with TSC in a randomized control trial of the JASPER behavioral intervention. At baseline, participants presented with heterogenous profiles of seizure frequency, GABAergic medication use, and presence of infantile spasms. The profile of each participant is depicted as a column of three shaded rectangles reflecting the presence (dark gray), absence (white), or history (light gray) of each clinical feature. For example, participant #18 outlined in red was reported at baseline to experience seizures at least monthly over the last two months; not to take a GABAergic medication; and to have a history of infantile spasms but not currently experience infantile spasms. Seizure severity scores are derived from the E-Chess [45] and incorporate the frequency of seizures, types of seizures (including infantile spasms), and number of anti-epileptic mediations (all classes)