Region | Median (IQR) volume (mm3) | P-value* | ||
---|---|---|---|---|
22qDS cohort (N = 7) | Cardiac cohort (N = 14) | Control cohort (N = 12) | ||
Total Brain Tissue | 180,336 (175,915 − 195,722) | 186,532 (178,217 − 191,228) | 187,245 (185,085–205,130) | 0.43 |
Cortical grey matter | 52,904 (47,848 − 60,194) | 49,686 (47,099 − 53,381) | 51,802 (46,823 − 56,184) | 0.80 |
White matter | 106,555 (102,600 − 109,962) | 111,804 (108,100–116,302) | 117,391 (113,012–125,685) | 0.031 |
Deep grey matter | 10,657 (9,476 − 10,982) | 9,603 (9,344 − 10,213) | 9,644 (9,299 − 10,226) | 0.42 |
Cerebellum | 9,604 (9,340 − 10,010) | 9,307 (8,565-9,848) | 9,333 (8,648 − 10,188) | 0.71 |
Cerebrospinal fluid | 100,118 (90,140 − 10,1103) | 88,321 (81,403 − 93,980) | 89,614 (84,471 − 94,621) | 0.26 |
Intracranial volume | 280,454 (262,938 − 304,093) | 271,201 (264,824 − 293,489) | 277,345 (273,772 − 306,111) | 0.85 |