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Table 2 Total and regional brain volumes for each of the three cohorts

From: An exploratory fetal MRI study examining the impact of 22q11.2 microdeletion syndrome on early brain growth

Region

Median (IQR) volume (mm3)

P-value*

22qDS cohort

(N = 7)

Cardiac cohort

(N = 14)

Control cohort

(N = 12)

Total Brain Tissue

180,336

(175,915 − 195,722)

186,532

(178,217 − 191,228)

187,245

(185,085–205,130)

0.43

Cortical grey matter

52,904

(47,848 − 60,194)

49,686

(47,099 − 53,381)

51,802

(46,823 − 56,184)

0.80

White matter

106,555

(102,600 − 109,962)

111,804

(108,100–116,302)

117,391

(113,012–125,685)

0.031

Deep grey matter

10,657

(9,476 − 10,982)

9,603

(9,344 − 10,213)

9,644

(9,299 − 10,226)

0.42

Cerebellum

9,604

(9,340 − 10,010)

9,307

(8,565-9,848)

9,333

(8,648 − 10,188)

0.71

Cerebrospinal fluid

100,118

(90,140 − 10,1103)

88,321

(81,403 − 93,980)

89,614

(84,471 − 94,621)

0.26

Intracranial volume

280,454

(262,938 − 304,093)

271,201

(264,824 − 293,489)

277,345

(273,772 − 306,111)

0.85

  1. Total brain tissue volumes and volumes of different intracerebral tissue types for each of the three groups: 22q, matched cardiac and matched control fetuses
  2. * P-value derived from Kruskal-Wallis test. Values in bold are considered significant