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Table 4 Medical history

From: Protein-truncating variants and deletions of SHANK2 are associated with autism spectrum disorder and other neurodevelopmental concerns

Symptom

N

Percentage

Hypotonia

7/10

70%

Otitis Media

6/9

67%

GI Tract Abnormalities

5/10

50%

 Constipation

5/10

50%

 Gastroesophageal Reflux Disease (GERD)

1/10

10%

Tympanostomy

4/9

44%

Gait Abnormalities

4/10

40%

 Toe walking

3/10

30%

 Orthotics for ankle support

1/10

10%

 Knee hyperextension

1/10

10%

Sleeping Problems

4/10

40%

 Difficulty falling asleep

4/10

40%

 Difficulty staying asleep

3/10

30%

 Waking early

1/10

10%

Feeding Issues

3/10

30%

 Chewing

2/10

20%

 Swallowing

2/10

20%

 Difficulty latching

1/10

10%

Vision Abnormalities

2/10

20%

 Amblyopia

1/10

10%

 Hyperopia

1/10

10%

 Strabismus

1/10

10%

Hearing Abnormalities, since corrected

2/10

20%

Allergies

2/10

20%

Psoriasis/Dermatitis

1/9

11%

Febrile Seizure (1x)

1/10

10%

  1. Legend: Reported medical history from most to least frequent. *One caregiver did not answer all questions on medical history form