Table 3 Metabolite set enrichment analyses (MSEA) revealed biologically meaningful metabolite sets disrupted in ASD pregnancies. sets containing at least 2 metabolites were significantly (P < 0.05) overrepresented by metabolites altered in cord blood of ASD versus neurotypical pregnancies. “Hits” describe overlapping metabolites between MSEA metabolite set and those differentially expressed between ASD and control samples. “Total set size” describes the total number of metabolites contained within each annotated set (Metaboanalyst)
From: Disrupted fetal carbohydrate metabolism in children with autism spectrum disorder
Metabolite Set | Total Set Size | Hits | Q Statistic | P value |
|---|---|---|---|---|
Fructose and Mannose Degradation | 31 | 3 | 17.193 | 0.0007 |
Galactose Metabolism | 38 | 6 | 9.9332 | 0.0011 |
Starch and Sucrose Metabolism | 31 | 3 | 12.519 | 0.0013 |
Pentose Phosphate Pathway | 29 | 4 | 9.6355 | 0.0022 |
Inositol Metabolism | 30 | 2 | 11.853 | 0.0032 |
Inositol Phosphate Metabolism | 24 | 2 | 11.853 | 0.0032 |
Glycolysis | 23 | 6 | 8.23 | 0.0038 |
Selenoamino Acid Metabolism | 27 | 2 | 9.9321 | 0.0050 |
Amino Sugar Metabolism | 33 | 6 | 8.5245 | 0.0078 |
Gluconeogenesis | 33 | 8 | 7.0914 | 0.0079 |
Valine, Leucine and Isoleucine Degradation | 59 | 9 | 6.7813 | 0.0107 |
Propanoate Metabolism | 42 | 5 | 7.526 | 0.0123 |
Warburg Effect | 57 | 16 | 5.4267 | 0.0151 |
Tryptophan Metabolism | 59 | 8 | 5.5524 | 0.0162 |
Purine Metabolism | 73 | 9 | 4.9873 | 0.0202 |
Steroid Biosynthesis | 43 | 2 | 6.2884 | 0.0391 |