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Table 3 Multilevel models of amyloid at baseline predicting RSMB

From: Behavioral and psychological symptoms of dementia and Alzheimer’s disease progression in Down syndrome

 

Estimates

RSMB

Fixed Effects

B

SE

t

df

95% CI

Aggression

Intercept

0.174

0.142

1.220

214

[−0.106, 0.453]

Time

0.009

0.016

0.590

507

[−0.022, 0.041]

Amyloid-β

0.004

0.002

1.550

507

[−0.001, 0.008]

Restricted/Repetitive

Intercept

0.004

0.092

0.050

214

[−0.177, 0.186]

Time x Amyloid-β

0.002

0.001

2.900**

506

[0.001, 0.003]

Depression-Behavior

Intercept

0.478

0.121

3.950***

214

[0.239, 0.716]

Time x Amyloid-β

0.002

0.001

2.880**

506

[0.001, 0.003]

Depression-Physical

Intercept

0.599

0.177

3.390***

214

[0.250, 0.947]

Time x Amyloid-β

0.002

0.001

2.940**

506

[0.001, 0.003]

Avoidant

Intercept

0.134

0.137

0.980

214

[−0.135, 0.403]

Time

0.047

0.019

2.500*

507

[0.010, 0.083]

Amyloid-β

0.005

0.002

2.010*

507

[0.000, 0.009]

Dependent

Intercept

0.521

0.137

3.800***

214

[0.251, 0.790]

Time

0.001

0.019

−0.040

507

[−0.038, 0.036]

Amyloid-β

0.004

0.002

1.660

507

[−0.001, 0.008]

Psychosis

Intercept

0.205

0.109

1.890

214

[−0.009, 0.419]

Time x Amyloid-β

0.002

0.000

4.630***

506

[0.001, 0.003]

Paranoia

Intercept

0.238

0.099

2.410*

214

[0.043, 0.433]

Time x Amyloid-β

0.002

0.000

3.470***

506

[0.001, 0.002]

Total

Intercept

1.889

0.540

3.500***

214

[0.826, 2.953]

Time x Amyloid-β

0.008

0.002

4.000***

506

[0.004, 0.012]

  1. N = 221. Unstandardized coefficients (Bs) are presented. RSMB = Reiss Screen for Maladaptive Behavior. All models include a random intercept and control for study site, age at baseline, sex, APOE ϵ4 carrier status, premorbid intellectual disability, psychiatric medications, and psychiatric diagnoses. Main effects were entered into models with interactions
  2. *** p < .001. ** p < .01. * p < .05