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Table 4 Multilevel models of tau at baseline predicting RSMB

From: Behavioral and psychological symptoms of dementia and Alzheimer’s disease progression in Down syndrome

 

Estimates

RSMB

Fixed Effects

B

SE

t

df

95% CI

Aggression

Intercept

−0.068

0.626

−0.110

136

[−1.307, 1.170]

Time

−0.002

0.016

−0.150

327

[−0.035, 0.030]

Tau

0.281

0.528

0.560

327

[−0.757, 1.319]

Restricted/Repetitive

Intercept

−0.594

0.323

−1.840

136

[−1.232, 0.044]

Time

0.004

0.013

0.350

327

[−0.021, 0.030]

Tau

0.540

0.271

1.990*

327

[0.006, 1.073]

Depression-Behavior

Intercept

−0.726

0.374

−1.940

136

[−1.466, 0.014]

Time

0.018

0.019

0.97

327

[−0.019, 0.055]

Tau

0.950

0.314

3.010**

327

[0.328, 1.563]

Depression-Physical

Intercept

−0.094

0.757

−0.120

136

[−1.591, 1.403]

Time x Tau

0.515

0.158

3.270**

326

[0.205, 0.825]

Avoidant

Intercept

−1.280

0.528

−2.420*

136

[−2.324, −0.236]

Time

0.047

0.021

2.210*

327

[0.005, 0.088]

Tau

1.365

0.444

3.08**

327

[0.492, 2.238]

Dependent

Intercept

−0.855

0.538

−1.590

136

[−1.920, 0.209]

Time

0.014

0.020

0.700

327

[−0.025, 0.054]

Tau

1.153

0.453

2.550*

327

[0.262, 2.043]

Psychosis

Intercept

−0.392

0.445

−0.880

136

[−1.273, 0.489]

Time x Tau

0.289

0.094

3.060**

326

[0.103, 0.475]

Paranoia

Intercept

−0.191

0.345

−0.550

136

[−0.874, 0.492]

Time

0.023

0.014

1.620

327

[−0.005, 0.051]

Tau

0.310

0.290

1.070

327

[−0.261, 0.881]

Total

Intercept

−1.470

2.224

−0.660

136

[−5.870, 2.925]

Time x Tau

1.305

0.393

3.320**

326

[0.532, 2.078]

  1. N = 143. Unstandardized coefficients (Bs) are presented
  2. All models include a random intercept and control for study site, age at baseline, sex, APOE ϵ4 carrier status, premorbid intellectual disability, psychiatric medications, and psychiatric diagnoses. Main effects were entered into models with interactions
  3. RSMB Reiss Screen for Maladaptive Behavior
  4. *** p < .001. ** p < .01. * p < .05