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Fig. 5 | Journal of Neurodevelopmental Disorders

Fig. 5

From: Transcriptomic profiling of unmethylated full mutation carriers implicates TET3 in FMR1 CGG repeat expansion methylation dynamics in fragile X syndrome

Fig. 5

TET3 expression differences between mouse and human. (a) Multiple sequence alignment of TET3 isoforms present in mouse, human and rhesus. (b) TET3 basemean expression levels in human and rhesus cortical organoids over 5 weeks of development. (c) Relative TET3 expression in cortical organoids generated from FXS iPSCs and grown over 60 days. 1-way ANOVA, Tukey’s multiple comparison test: **** p < 0.001, ns not significant. (d) TPM expression values for TET3 in the mouse and human forebrain at different age points. Note dual y-axes and scaling. (e) TPM expression values for FMR1 in the human and mouse dorsolateral prefrontal cortex at different age points

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Journal of Neurodevelopmental Disorders

ISSN: 1866-1955

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