Fig. 2

Visualization of Salience-Visual Screening Statistics for Social Affect Scores in Brain Space. Matrix depicts enrichment analysis screening statistics across networks (left panel). Upper triangle displays a heatmap of t-statistics assessing associations between functional connectivity (fc) values and social affect (SA) scores for reach ROI pair (dot in matrix), organized by network: Vis = visual, DMN = default mode network, SMD = somatomotor dorsal, SML = somatomotor lateral, AUD = auditory, DAN = dorsal attention network, VAN = ventral attention network, PMN = parietomedial network, FP = frontoparietal, CO = cingulo-opercular, MTL = medial temporal lobe, REWARD = reward network, SAL = salience. ROIs within each network-network block are organized such that subcortical and cerebellar ROIs are presented first, followed by cortical ROIs. The top left block of the matrix depicts brain-behavior associations in the SAL-VIS network, demonstrating that the vast majority of the positive t-stats (red) are within cortical-cortical ROI pairs. Lower triangles are thresholded to display the strongest brain-behavior associations (top 2.5% of positive and negative t-statistics, or “hits”), colored by whether the t-statistic is positive (red) or negative (blue). The bottom right block of the matrix (green) shows that the vast majority of hits within SAL-VIS are positive, indicating that stronger fc between ROIs in SAL-VIS is associated with higher levels of SA impairment. Visualization of top hits in brain space (right panel)