Table 3 Results of ROI-analysis for the contrast controls > 47,xxx. Significant rois with D.creased GM volume in 47,XXX (all p < .05; Holm-Bonferroni-corr.). Effect sizes are reported as Cohen’s D

Limbic

Amygdala

11.47

0.000001

3.51

Amygdala

7.78

0.000001

2.38

Hippocampus

5.38

0.000189

1.64

Hippocampus

4.41

0.004718

1.35

Parahippocampal g.

6.11

0.000012

1.87

Entorhinal cortex

6.58

0.000005

2.01

Entorhinal cortex

5.25

0.000273

1.61

Anterior insula

6.69

0.000002

2.05

Anterior insula

6.62

0.000003

2.02

Posterior insula

6.39

0.000004

1.95

Posterior insula

5.28

0.000103

1.61

Subcortical

Putamen

6.59

0.000005

2.01

Putamen

5.75

0.000036

1.76

Ncl. Accumbens

4.56

0.003110

1.39

Ventral DC

3.93

0.019503

1.20

Ventral DC

5.48

0.000158

1.68

Thalamus proper

3.17

0.029940

0.97

Thalamus Proper

4.00

0.010376

1.22

Cerebellum ext.

5.76

0.000020

1.76

Cerebellum ext.

6.23

0.000012

1.90

Frontal lobe

Medial orbital

6.63

0.000003

2.03

Medial orbital

5.75

0.000047

1.76

Anterior orbital

5.27

0.000014

1.61

Anterior orbital

6.16

0.000003

1.88

Posterior orbital

4.45

0.004015

1.36

Posterior orbital

4.90

0.000018

1.50

Lateral orbital g.

3.58

0.023680

1.09

Superior frontal

4.74

0.000060

1.45

Superior frontal

4.02

0.011879

1.23

Sup. frontal medial

4.74

0.001381

1.45

Inferior frontal g.

3.56

0.030884

1.09

Frontal pole

3.56

0.037372

1.09

G. rectus

3.41

0.018745

1.04

G. rectus

3.41

0.005490

1.04

Basal forebrain

4.01

0.011522

1.23

Basal forebrain

4.32

0.005520

1.32

Subcallosal area

5.13

0.000096

1.57

Subcallosal area

5.65

0.000014

1.73

Middle cingulate

3.44

0.049012

1.05

Posterior cingulate

4.09

0.012901

1.25

Precentral

4.50

0.002689

1.38

Precentral

4.06

0.003738

1.24

Central operculum

3.55

0.014029

1.09

Frontal operculum

2.91

0.017958

0.89

Temporal lobe

Occipital fusiform

3.70

0.035047

1.13

Occipital fusiform

5.26

0.000255

1.61

Fusiform

4.20

0.003025

1.28

Fusiform

4.12

0.007791

1.26

Inferior temporal

5.30

0.000065

1.62

Inferior temporal

4.78

0.001426

1.46

Superior temporal

4.08

0.001235

1.25

Superior temporal

4.54

0.001499

1.39

Temporal pole

4.73

0.000046

1.45

Temporal pole

4.26

0.001859

1.30

Planum polare

4.00

0.008862

1.22

Middle temporal

3.79

0.021667

1.16

Middle temporal

4.38

0.000675

1.34

Lingual

4.24

0.007276

1.30

Angular

4.36

0.004887

1.33

Occipital lobe

Inferior occipital

5.71

0.000070

1.75

Inferior occipital

4.13

0.001732

1.26

Middle occipital

3.85

0.026919

1.18

Superior occipital

2.12

0.020396

0.65